216 papers
Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.
At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.
Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.
This study demonstrates that apical H-spectrin (SMA-1) organizes cortical actin filament bundles in the *C. elegans* epidermis, which is essential for patterning collagen-rich cuticle ridges by preventing excessive matrix delamination.
This study demonstrates that Hippo signaling differentially regulates distinct SOX9+ progenitor subpopulations and their transitional states to control lung size through bifurcation and specify cell fates for conducting airways and alveolar epithelium, providing a comprehensive developmental map of mammalian lung construction.
This paper proposes Distribution-Aware Federated Learning (DA-FL), a novel framework that combines client-specific minority-class amplification factors with class-weighted loss to effectively mitigate non-IID and class-imbalanced challenges in diabetes prediction, significantly outperforming conventional methods like FedAvg in accuracy and stability on the CDC BRFSS 2021 dataset.
This study reveals that transcriptional feedback within the Wnt pathway generates unexpected mRNA asymmetries in *C. elegans* seam cells that precede and reinforce cell fate decisions, uncovering hidden molecular heterogeneity that challenges established models of protein-based Wnt signaling.
This study characterizes the genomic organization and expression of the bovine DUXC gene in early embryos, providing the first full-length mRNA sequence and demonstrating that DUXC is expressed at pre-embryonic genome activation (EGA) stages with a subsequent decline dependent on minor EGA, suggesting its potential role as a bovine EGA inducer.
This study utilizes high-resolution spatial transcriptomics to reveal that zebrafish heart regeneration relies on the organization of macrophages into discrete cardio-immune microniches, where a specific fibroblast-macrophage axis (il34-csf1ra-egr1) orchestrates pro-regenerative states, while its disruption shifts macrophages toward pro-fibrotic inflammation and impairs tissue repair.
Using intravital multiphoton imaging, this study reveals that skin capillary endothelial cells maintain a spatiotemporally conserved network of Ca2+ activity regulated by Connexin 43-mediated communication, where the loss of Cx43 causes sustained signaling and vascular dysfunction that can be non-cell-autonomously rescued by inhibiting L-type Ca2+ channels.
This study establishes a spatial and temporal atlas of tubulin isotype expression during chick neural crest epithelial-to-mesenchymal transition, revealing a systematic reprogramming of cytoskeletal architecture that coordinates microtubule composition with cell state transitions.
This study presents the first genome-wide analysis of all ten *C. elegans* DMRT genes, revealing that six exhibit sexually dimorphic expression in novel tissues and that their loss causes diverse neuronal differentiation defects, while also highlighting roles for some family members beyond sexual differentiation.
This study reveals that during *Clytia hemisphaerica* embryogenesis, neural cell types arise through two distinct pathways: nematocytes and some ganglionic neurons originate from Piwi/Nanos-expressing interstitial stem cells, while sensory neurons and secretory cells develop via ectodermal delamination during gastrulation.